Geetika Aggarwal

This study shows that progranulin deficiency increases NLRP3 inflammasome activity via cathepsin B, leading to neuroinflammation, and demonstrates that ASO treatment can reverse this effect in GRN-deficient cells.

The paper investigates how mutations in the J-domain of DNAJB6 affect chaperone function and inter-domain interactions, providing mechanistic insights into LGMDD1 myopathy.

This study characterizes the GrnR493X mouse model of frontotemporal dementia, finding similar phenotypes to Grn knockout models but with differences in biomarker levels in heterozygous mice.

This study shows that antisense oligonucleotides can increase progranulin protein levels by blocking miR-29b binding in GRN mRNA, offering a potential therapy for FTD.