Subhashis Banerjee

This study shows that progranulin deficiency increases NLRP3 inflammasome activity via cathepsin B, leading to neuroinflammation, and demonstrates that ASO treatment can reverse this effect in GRN-deficient cells.

This study uses dual lineage tracing to show irradiation reduces SMC investment in atherosclerotic lesions and increases EC-derived cells, leading to reduced plaque stability.

This study shows that chronic CBD administration improves learning and memory and reduces anxiety in aged SAMP8 mice, with potential therapeutic implications for age-related cognitive decline.

This study characterizes the GrnR493X mouse model of frontotemporal dementia, finding similar phenotypes to Grn knockout models but with differences in biomarker levels in heterozygous mice.

This study shows that antisense oligonucleotides can increase progranulin protein levels by blocking miR-29b binding in GRN mRNA, offering a potential therapy for FTD.