Author

Nicholas Economos

ORCID 0000-0003-4691-808XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

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F. Nina Papavasiliou· 1 shared Pete Stavropoulos· 1 shared Rebecca K Delker· 1 shared

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2018-2018 · peak 1/yr

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1 shared paperImmunology

F. Nina Papavasiliou

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintNov 14, 2018

Genetic loss of the ubiquitin ligase RNF126, an AID interacting partner and modifier, affects strand targeting during somatic hypermutation of antibody genes

Nicholas Economos, Rebecca K Delker, Pete Stavropoulos, F. Nina Papavasiliou

This study shows that RNF126 ubiquitination of AID is necessary for proper strand targeting during SHM, leading to G>C mutation bias and reduced indels in the variable region.

DOI 10.1101/469775

mouseDNA methylation

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