José Carlos Gómez-Tamayo

This study determines the structures of human Malic Enzyme 3 (ME3) in various ligand binding states, revealing its tetrameric structure and dynamic Domain C, and provides insights into its non-allosteric nature and potential for drug development.

TMSNP predicts pathogenicity of missense mutations in transmembrane regions of membrane proteins using a machine-learning model trained on curated mutation data.