Mireia Olivella

SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex

This study identifies SIRT1's role in regulating DNA damage signaling via interaction with the PP4 phosphatase complex, showing SIRT1 inhibits PP4 to modulate key DDR markers.

TMSNP: a web server to predict pathogenesis of missense mutations in transmembrane region of membrane proteins

TMSNP predicts pathogenicity of missense mutations in transmembrane regions of membrane proteins using a machine-learning model trained on curated mutation data.

DIMERBOW: exploring possible GPCR dimer interfaces

DIMERBOW provides a database and web tool to explore potential GPCR dimer interfaces from solved structures to aid in modeling homomers.

SirT7 auto-ADP-ribosylation regulates glucose starvation response through macroH2A1.1

This study identifies SirT7's dual role as a deacetylase and mADPRT enzyme, showing its regulation of glucose starvation response via interaction with macroH2A1.1.