Jeffrey Allen Norton

The paper constructs a pan-cancer single-cell atlas to improve tumor identity inference and identify genetic vulnerabilities by integrating high-quality malignant cells across multiple cancers.

This study uses single-cell and spatial transcriptomics to identify distinct tumor states in uterine leiomyosarcomas and proposes drug targets based on these states.

The paper uses integrated spatial multi-omics to study fibroblast fate during tissue repair and defines mechanisms controlling cell fate in wound healing.

Northstar automatically classifies known and novel cell types from tumor samples with high accuracy and robustness.