Michael Thornton Longaker

The paper constructs a pan-cancer single-cell atlas to improve tumor identity inference and identify genetic vulnerabilities by integrating high-quality malignant cells across multiple cancers.

This study uses single-cell and spatial transcriptomics to identify distinct tumor states in uterine leiomyosarcomas and proposes drug targets based on these states.

The paper identifies TREM2-p53 signaling as a determinant of oxygen-induced lung injury in mice, showing that TREM2 loss reduces inflammation and improves lung development.

The paper identifies cis-regulatory variation in MRL mice associated with ear regeneration using allele-specific expression analysis.

The paper uses integrated spatial multi-omics to study fibroblast fate during tissue repair and defines mechanisms controlling cell fate in wound healing.

This study shows that endothelial CXCL12 is crucial for neovascularization in tissue repair and tumor progression by regulating endothelial-fibroblast interactions and recruiting neovascularization-supporting cells.

This study shows Spen binds to endogenous retroviral RNAs and recruits chromatin silencing machinery, linking RNA-mediated retrovirus silencing to X chromosome inactivation.

On patterned flow cells using exclusion amplification, up to 5-10% of reads are credited to the wrong sample in a pool, traced to free index primers surviving library cleanup.