Brendan F. Kennedy

This study develops a 3D ECM micro-rods system to guide liver periportal tubulogenesis in hIPSC organoids, demonstrating scalable and quantifiable recapitulation of bile duct and vascular development.

This paper introduces a new optical coherence elastography technique that maps Euler angles to improve breast cancer detection by accounting for tissue heterogeneity.

This study uses 3D micro-elastography to analyze changes in ovarian elasticity patterns in mice across different ages, revealing age-related differences in follicles and corpora lutea.

This study uses multimodal mechano-microscopy to analyze mechanical properties of breast cancer spheroids in 3D environments, revealing differences in elasticity and invasion behavior between non-metastatic and metastatic spheroids.

This study trains a conditional generative adversarial network to estimate tumor spheroid elasticity from phase difference images, showing improved robustness to noise compared to traditional methods.

The paper introduces a method to create barcoded 3D cell cultures for spatial single-cell analysis using polymer-mediated oligonucleotide delivery and multiplex single-cell RNA sequencing.