Cameron W. Evans

This paper develops a non-viral CRISPR/dCas9-KRAB system for epigenetic silencing of oncogenic transcription factors in Ewing Sarcoma, showing effective tumor suppression in cell line and patient-derived xenograft models.

The paper identifies over 650,000 i-motif structures in human genomic DNA using immunoprecipitation and sequencing, showing their widespread distribution and association with highly expressed genes and G0/G1 phase upregulated genes.

The paper introduces a method to create barcoded 3D cell cultures for spatial single-cell analysis using polymer-mediated oligonucleotide delivery and multiplex single-cell RNA sequencing.

The paper introduces a new multiplexed single-cell sequencing method to identify metastable cell states during EMT and shows G-quadruplex DNA stabilization can inhibit EMT.