Chii Jou Chan

This study shows enzymatic remodeling of aged cardiac ECM reduces stiffness but preserves contractility and some age-related transcriptional features in ex vivo myocardial slices.

The paper develops a theoretical framework to explain how cells sense and respond to surface curvature, showing that both mean and Gaussian curvature influence cell orientation and migration.

This study investigates how theca cell mechanosensing and extracellular matrix properties regulate ovarian follicle development in mice.

The paper investigates the spatiotemporal dynamics of lumen formation in mammalian follicles, revealing a critical phenomenon involving fluid networks and cell death.

This study uses 3D micro-elastography to analyze changes in ovarian elasticity patterns in mice across different ages, revealing age-related differences in follicles and corpora lutea.

This study shows that theca cells regulate ovarian follicle growth through mechanical signaling and tissue pressure, affecting granulosa cell behavior and oocyte development.

The paper shows how cell fate-specific changes in osmotic and actomyosin forces coordinate robust organoid morphogenesis through lumen volume reduction and mechanical tension.

This study shows that lumen expansion in mouse blastocysts is critical for epiblast and primitive endoderm fate specification and spatial segregation.

This study investigates how lumenal pressure and tissue mechanics regulate embryonic size and cell fate during mouse blastocyst development.