Author

Falk Hertwig

Humboldt-Universität zu BerlinORCID 0000-0003-4784-6516Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:statistical model· 1

Frequent Co-Authors

Angelika EggertiD· 2 shared Anton George HensseniD· 2 shared Johannes Hubertus SchulteiD· 2 shared Kathy AstrahantseffiD· 2 shared Konstantin HelmsaueriD· 2 shared Marco LodriniiD· 2 shared Steffen FuchsiD· 2 shared Alice VitaliiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

Angelika EggertORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 12, 2026

Quantitative and sensitive neuroblastoma minimal residual disease detection using extrachromosomal DNA (ecDNA) breakpoints

Annabell Szymansky, Falk Hertwig, Annika Winkler…·Johannes Hubertus Schulte

This study develops a method to detect minimal residual disease in neuroblastoma using ecDNA breakpoints, achieving high sensitivity and specificity in bone marrow samples.

DOI 10.64898/2026.09.06.749680

humanwhole-genome sequencing

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ImmunologyPharmacological ResearchPeer-reviewedJan 18, 2025

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy

Laura Grunewald, Lena Andersch, Konstantin Helmsauer…·Annette Künkele

This paper shows that high MYCN levels in neuroblastoma reduce L1CAM expression, limiting CAR T cell efficacy, and that inhibiting MYCN with MLN8237 restores L1CAM and enhances CAR T cell activity.

8 citations

humanbulk RNA-seq

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