Author

Peng Zheng

Nanjing Drum Tower HospitalORCID 0000-0003-4792-6364Unclaimed ORCID profile · follow to get notified of new preprints

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Peng Zheng1 paper

Biology Disciplines

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Biophysics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:imputation· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Bin ZhengiD· 2 shared Guojin Tang· 2 shared Jun QiuiD· 2 shared Bin JiaiD· 1 shared Lichao LiuiD· 1 shared Lin ChengiD· 1 shared Meimei Duan· 1 shared Shangchen Wang· 1 shared

Activity by Year

2022-2025 · peak 1/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Bin ZhengORCID

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3 papers

Recent·Most cited

Transforming a Fragile Protein Helix into an Ultrastable Scaffold via a Hierarchical AI and Chemistry Framework

Jun Qiu, Guojin Tang, Tianfu Feng, Bin Zheng, Yuanhao Liu, Peng Zheng

This paper designs ultrastable helical proteins using AI and chemistry, achieving high mechanical, thermal, and chemical stability.

bioRxiv · Nov 3, 2025 · PreprintBiophysics

Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations

Bin Zheng, Meimei Duan, Yifen Huang, Shangchen Wang, Jun Qiu, Zhuojian Lu, Lichao Liu, Guojin Tang, Lin Cheng, Peng Zheng

The paper identifies a conserved heparan sulfate binding domain in MPXV H3 using AI and MD simulations, validates its role in viral adhesion, and demonstrates a protein inhibitor that disrupts this interaction, inhibiting infection in vitro and in vivo.

eLife · Aug 13, 2024Peer-reviewedBiophysics

OaAEP1-mediated PNA-protein conjugation enables erasable imaging of membrane protein

Zhangwei Lu, Yutong Liu, Yibing Deng, Bin Jia, Xuan Z. Ding, Peng Zheng, Zhe Li

This paper introduces a method for site-specific conjugation of proteins to PNA using a strict protein ligase, enabling erasable imaging of membrane proteins.

Chemical Communications · Jan 1, 2022Peer-reviewedMolecular Biology