Kira E. Poskanzer

AQuA2 quantifies molecular spatiotemporal signals from live imaging data by decomposing complex datasets into signaling events, demonstrating applications across biosensors and cell types.

The paper shows that local neurotransmitter inputs drive widespread astrocyte calcium responses and propagative events that gate future network activity.

This paper develops a photo-activatable norepinephrine compound to enable precise spatial control of NE release for studying noradrenergic circuits in the CNS.

The paper shows that dopamine activates PFC astrocytes via α1-adrenergic receptors, leading to calcium signals and regulation of extracellular ATP.

The paper investigates how astrocytic Gi-GPCR activation affects extracellular glutamate and GABA levels in response to visual stimuli, finding increased glutamate but not GABA dynamics.

This paper describes the design and implementation of a deformable mirror-based two-photon microscope for axial mammalian brain imaging, demonstrating its capabilities through calibration and sample imaging.

The paper introduces AQuA, an event-based analysis tool for astrocyte imaging data, revealing novel single-cell and population-level physiological phenomena.