Author

Xuelong Mi

Virginia Tech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 5 Approach:experimental assay· 4 Research Focus:cell-cell communication· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:machine learning (classical)· 2 Organism:zebrafish· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Guoqiang YuiD· 3 shared Guoqiang Yu· 3 shared Misha B. AhrensiD· 3 shared Alex CheniD· 2 shared Axel NimmerjahniD· 2 shared Daniela Duarte· 2 shared Dwight E. BerglesiD· 2 shared Erin M. Carey· 2 shared

Activity by Year

2018-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Guoqiang YuORCID

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6 papers

Recent·Most cited

Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain

Vered Kellner, Patrick Parker, Dongeun Heo, Xuelong Mi, Mikhail Coen, Guoqiang Yu, Gesine Saher, Loyal A. Goff, Dwight E. Bergles

The paper shows that retinal ganglion cell activity induces correlated astrocyte calcium waves in the superior colliculus, dependent on mGluR5 and mGluR3, suggesting a conserved mechanism across sensory systems.

Glia · Mar 26, 2026Peer-reviewedNeuroscience

AQuA2-Cloud: a web platform for fluorescence bioimaging activity analysis

Mark Bright, Xuelong Mi, Daniela Duarte, Erin M. Carey, Boyu Lyu, Yihzi Wang, Axel Nimmerjahn, Guoqiang Yu

AQuA2-Cloud provides a web platform for analyzing fluorescence bioimaging data, enabling cloud-based activity quantification with improved accessibility and usability compared to the original AQuA2 tool.

bioRxiv · Mar 10, 2026 · PreprintBioinformatics

Astrocyte-induced internal state transitions reshape brainwide sensory, integrative, and motor computations

Jing-Xuan Lim, Ziqiang Wei, Sujatha Narayan, Yan Zhang, Jeremy P. Hasseman, Ilya Kolb, Jihong Zheng, Alireza Sheikhattar, Xuelong Mi, Wei Hui Zheng, X. William Yang, Mariam Beriashvili, Greg M. Fleishman, Caroline Lei Wee, De Zeeuw Ci, , Misha B. Ahrens

The paper shows that astrocyte activity drives brainwide changes in sensory, integrative, and motor computations during a passive state in zebrafish.

bioRxiv · Feb 5, 2026 · PreprintNeuroscience

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

Xuelong Mi, Alex Chen, Daniela Duarte, Erin M. Carey, Charlotte R. Taylor, Philipp N. Braaker, Mark Bright, Rafael Almeida, Jing-Xuan Lim, Virginia M. S. Ruetten, Yizhi Wang, Mengfan Wang, Weizhan Zhang, Wei Hui Zheng, Michael E. Reitman, , Guoqiang Yu

AQuA2 quantifies molecular spatiotemporal signals from live imaging data by decomposing complex datasets into signaling events, demonstrating applications across biosensors and cell types.

Cell · Apr 8, 2025Peer-reviewedNeuroscience

Norepinephrine changes behavioral state via astroglial purinergic signaling

Alex Chen, Marc Duque, Vickie M. Wang, Mahalakshmi Dhanasekar, Xuelong Mi, Altyn Rymbek, Loeva Tocquer, Sujatha Narayan, David A. Prober, Guoqiang Yu, Claire Wyart, Florian Engert, Misha B. Ahrens

The paper shows norepinephrine induces astroglial purinergic signaling that suppresses behavior through adenosine receptor activation in zebrafish.

bioRxiv · May 23, 2024 · PreprintNeuroscience

An event-based paradigm for analyzing fluorescent astrocyte activity uncovers novel single-cell and population-level physiology

Yizhi Wang, Nicole V. DelRosso, Trisha V. Vaidyanathan, Michael E. Reitman, Michelle K. Cahill, Xuelong Mi, Guoqiang Yu, Kira E. Poskanzer

The paper introduces AQuA, an event-based analysis tool for astrocyte imaging data, revealing novel single-cell and population-level physiological phenomena.

bioRxiv · Dec 21, 2018 · PreprintNeuroscience