Author

Daniela Duarte

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5 Bioinformatics· 1

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Assay:imaging· 5 Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Approach:machine learning (classical)· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Axel NimmerjahniD· 6 shared Erin M. Carey· 4 shared Nicholas A. NelsoniD· 3 shared Alexander NgoiD· 2 shared Grace Gao· 2 shared Guoqiang YuiD· 2 shared Katharina MerteniD· 2 shared Mark BrightiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

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10 top collaborators · 28 mutual co-author links

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6 shared papersNeuroscience

Axel NimmerjahnORCID

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6 papers

Recent·Most cited

AQuA2-Cloud: a web platform for fluorescence bioimaging activity analysis

Mark Bright, Xuelong Mi, Daniela Duarte, Erin M. Carey, Boyu Lyu, Yihzi Wang, Axel Nimmerjahn, Guoqiang Yu

AQuA2-Cloud provides a web platform for analyzing fluorescence bioimaging data, enabling cloud-based activity quantification with improved accessibility and usability compared to the original AQuA2 tool.

bioRxiv · Mar 10, 2026 · PreprintBioinformatics

Modeling predicts a biochemical feedback mechanism underlying astrocyte calcium refractory periods

James Cheng Peng, Katharina Merten, Mary Kaye Duff, Nicholas A. Nelson, Yizhi Wang, Daniela Duarte, Yue Wang, Lin Tian, Axel Nimmerjahn, Guoqiang Yu

The paper develops a computational model of astrocytic calcium signaling that predicts refractory periods through a feedback mechanism involving cPKC, validated with in vivo imaging data.

bioRxiv · Jan 13, 2026 · PreprintNeuroscience

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

Xuelong Mi, Alex Chen, Daniela Duarte, Erin M. Carey, Charlotte R. Taylor, Philipp N. Braaker, Mark Bright, Rafael Almeida, Jing-Xuan Lim, Virginia M. S. Ruetten, Yizhi Wang, Mengfan Wang, Weizhan Zhang, Wei Hui Zheng, Michael E. Reitman, , Guoqiang Yu

AQuA2 quantifies molecular spatiotemporal signals from live imaging data by decomposing complex datasets into signaling events, demonstrating applications across biosensors and cell types.

Cell · Apr 8, 2025Peer-reviewedNeuroscience

Multiplex, translaminar imaging in the spinal cord of behaving mice

Pavel Shekhtmeyster, Erin M. Carey, Daniela Duarte, Alexander Ngo, Grace Gao, Nicholas A. Nelson, Charles L. Clark, Axel Nimmerjahn

This paper develops a new imaging system to study spinal cord activity in behaving mice, revealing lamina-specific calcium responses in astrocytes and pain-related activity in Tac1 neurons.

Nature Communications · Mar 21, 2023Peer-reviewedNeuroscience

Trans-segmental imaging in the spinal cord of behaving mice

Pavel Shekhtmeyster, Daniela Duarte, Erin M. Carey, Alexander Ngo, Grace Gao, Jack A. Olmstead, Nicholas A. Nelson, Axel Nimmerjahn

This study develops a wearable macroscope to image spinal cord activity in behaving mice and finds that painful stimuli trigger coordinated astrocyte excitation across multiple spinal segments.

Nature Biotechnology · Mar 6, 2023Peer-reviewedNeuroscience

Astrocytes encode complex behaviorally relevant information

Katharina Merten, Robert W. Folk, Daniela Duarte, Axel Nimmerjahn

The paper shows astrocytes encode behaviorally relevant information through calcium transients during a visual detection task, complementing neuronal coding.

bioRxiv · Oct 9, 2021 · PreprintNeuroscience