Thomas Nelson Harvey

Whole genome screening defines a key role of autophagy in resistance of bovine cells to BVDV infection

The paper identifies BVDV host resistance factors using a bovine whole genome knockout library, highlighting autophagy-related proteins as key to resistance.

Genome-wide CRISPR knockout screen reveals the landscape of essential genes across the porcine genome

The paper identifies essential genes in porcine cell lines using CRISPR screening and compares them to human essential genes.

Investigating antiviral pathways in Atlantic salmon cells through interferon receptor knockouts via CRISPR-Cas9

This study uses CRISPR-Cas9 to knockout IFN receptor genes in Atlantic salmon cells to assess their role in antiviral signaling against ISAV and IPNV, revealing gene-specific effects and alternative pathways.

The effect of dietary chitin on Atlantic salmon (Salmo salar) chitinase activity, gene expression, and microbial composition

This study examines how dietary chitin affects chitinase activity, gene expression, and gut microbial composition in Atlantic salmon.

The need for high-resolution gut microbiome characterization to design efficient strategies for sustainable aquaculture production

This study evaluates microbiota-directed fibers (MDFs) in Atlantic salmon diets, finding negligible effects on gut microbiome and host physiology, but identifying potential endogenous lactic acid bacteria for future MDF strategies.

The genome regulatory landscape of Atlantic salmon liver through smoltification

This study investigates the genome regulatory changes in Atlantic salmon liver during smoltification, finding that metabolic remodeling occurs in freshwater and transcription factor dynamics drive gene expression changes, while DNA methylation is not correlated with expression shifts.

Linking genomic prediction for muscle fat content in Atlantic salmon to underlying changes in lipid metabolism regulation

The paper links genomic prediction of muscle fat content in Atlantic salmon to changes in lipid metabolism by analyzing gene expression and eQTLs.

Efficient transfection of Atlantic salmon primary hepatocyte cells for functional assays and gene editing

This paper develops a method for efficiently transfecting Atlantic salmon primary hepatocytes for functional assays and gene editing.

Comparative transcriptomics reveals domestication-associated features of Atlantic salmon lipid metabolism

This study compares lipid metabolism in domesticated and wild Atlantic salmon fed different diets, finding domesticated salmon show distinct metabolic responses to vegetable oil.