Joris J. R. Louwen

The paper identifies novel biosynthetic gene clusters in marine sponge microbiomes associated with brominated alkaloids.

iPRESTO detects sub-clusters in biosynthetic gene clusters to link natural product substructures to their genetic origins, improving annotation and discovery.

NPOmix connects mass spectrometry fragmentation data to biosynthetic gene clusters using a k-nearest neighbor classifier, improving metabolite discovery and structure prediction.

MS2Query improves metabolite annotation by combining mass spectral embeddings and precursor masses to rank analogues and exact matches more reliably and scalably.