Sven van der Burg

This study investigates how neuromodulators like dopamine and acetylcholine regulate neuronal information transfer by altering functional domains in excitatory and inhibitory neurons.

The paper shows neuronal classification is dynamic, not static, by demonstrating input patterns significantly influence functional classification in mice cortical neurons.

iPRESTO detects sub-clusters in biosynthetic gene clusters to link natural product substructures to their genetic origins, improving annotation and discovery.

MS2DeepScore uses a Siamese neural network to predict structural similarity from mass fragmentation spectra, outperforming classical methods and enabling chemically meaningful spectral embeddings.

The paper shows mice habituate to repeated overhead visual stimuli but generalize freezing to novel shapes, indicating experience-dependent modulation of innate defensive responses.