Nicola Facchinello

This study identifies a GlcChol-RAC1-actin signaling axis linking GBA2 loss-of-function to synaptic and mitochondrial dysfunction in SPG46, with Rac1 inhibition rescuing disease phenotypes in a zebrafish model.

This study identifies endothelial RRM2B-dependent mitochondrial DNA signaling as a driver of doxorubicin-induced cardiotoxicity and shows that Eltrombopag can prevent it.

This study shows that ANTXR2 regulates COL6 turnover in skeletal muscle, and its deficiency leads to ECM stiffening and muscle dysfunction.

This paper identifies Y705 and S727 phosphorylation sites on STAT3 as critical for its mitochondrial import and transcriptional activity, which regulate stem cell proliferation in zebrafish and mouse models.