Francesco Argenton

Endothelial RRM2B-dependent mitochondrial DNA signalling drives doxorubicin-cardiotoxicity

This study identifies endothelial RRM2B-dependent mitochondrial DNA signaling as a driver of doxorubicin-induced cardiotoxicity and shows that Eltrombopag can prevent it.

STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia

This study shows that STAT3 and HIF1α work together to mediate hypoxia responses by physically interacting and enhancing HIF1α transcriptional activity.

Notch controls the cell cycle to define leader versus follower identities during collective cell migration.

This study shows Notch signaling controls cell cycle progression to define leader and follower identities during zebrafish Trunk Neural Crest migration.

Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells

This paper identifies Y705 and S727 phosphorylation sites on STAT3 as critical for its mitochondrial import and transcriptional activity, which regulate stem cell proliferation in zebrafish and mouse models.