Author

Jacob F. Degner

AbbVie (United States)ORCID 0000-0003-4898-8575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 4 Approach:statistical model· 4 Research Focus:GWAS / association mapping· 3 Organism:human· 3 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:eQTL / molecular QTL mapping· 1

Frequent Co-Authors

Emily A. KingiD· 3 shared J. Wade DavisiD· 2 shared Bridget M. Riley-GillisiD· 1 shared Fedik RahimoviD· 1 shared Fengjiao Dunbar· 1 shared FinnGeniD· 1 shared Howard J. JacobiD· 1 shared Jeffrey F. WaringiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Emily A. KingORCID

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4 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintSep 5, 2024

Integration of GWAS and multi-omic QTLs identifies uncharacterized COVID-19 gene-biotype and phenotype associations

Meritxell Oliva, Emily A. King, Reza K. Hammond…·Jacob F. Degner

The paper integrates GWAS and multi-omic QTLs to identify gene-biotype and phenotype associations related to COVID-19, revealing pleiotropy and causal links.

DOI 10.1101/2024.09.05.24313137

humanGWAS summary statistics

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Genetic & Genomic MedicinemedRxivPreprintJun 7, 2022

A meta-analysis of genome-wide association studies in 614,243 individuals identifies 59 novel susceptibility loci underlying Dupuytren's contracture

Fedik Rahimov, Jacob F. Degner, John S. Lee…·Jeffrey F. Waring

DOI 10.1101/2022.06.07.22276119

humanGWAS summary statistics

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BioinformaticsBMC BioinformaticsPeer-reviewedMay 17, 2021

Estimating colocalization probability from limited summary statistics

Emily A. King, Fengjiao Dunbar, J. Wade Davis, Jacob F. Degner

The paper introduces POEMColoc, a method to estimate colocalization probability using limited summary statistics, and finds evidence for colocalization between 150,000 trait-gene-tissue triplets.

13 citations

GWAS summary statisticsstatistical model

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedDec 12, 2019

✦ In-depth digest

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval.

Emily A. King, J. Wade Davis, Jacob F. Degner

Updated pipeline and genetic data confirm genetically supported drug targets succeed more often; Mendelian (OMIM) support replicates prospectively, while GWAS support is weaker unless coding-linked.

649 citationstop 1%

humanGWAS summary statistics

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