Yanis Zekri

This paper identifies IRE1 activity as a regulator of prostate cancer cell lineage states and shows its role in predicting prognosis and treatment response across localized and metastatic disease.

This study shows that thyroid hormone signaling in brown adipocytes is essential for thermogenesis by regulating lipid and glucose metabolism and BAT proliferation.

The paper compiles RNA-seq and ChIP-seq data to create an atlas of thyroid hormone receptor target genes in mouse tissues, revealing variations in target gene repertoires and factors influencing hormonal response.

The paper uses synthetic STARR-seq to identify functional thyroid hormone response elements by assessing DNA-binding affinity and transactivation activity of TR1-RXR heterodimers.