The paper creates a spatial transcriptomic atlas of pediatric brain tumors, identifying spatial archetypes and relapse-associated clones across multiple diagnoses.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer.

Dimitrios Doultsinos, Ingrid Tomljanović, Eleftherios D. Pilalis, Sophia M. Abusamra, Romuald Parmentier, I.E. Bridges, Sandy Figiel, Yanis Zekri, Joanna Hester, Damien A. Leach, Charlotte Lynne Bevan, Alastair D.G. Lamb, Wilbert T. Zwart, Aristotelis A. Chatziioannou, Clémentine Le Magnen, Ian Geoffrey Mills

This paper identifies IRE1 activity as a regulator of prostate cancer cell lineage states and shows its role in predicting prognosis and treatment response across localized and metastatic disease.

bioRxiv · Mar 13, 2025 · PreprintCancer Biology

Molecular analysis of archival diagnostic prostate cancer biopsies identifies genomic similarities in cases with progression post-radiotherapy, and those with de novo metastatic disease.

Philip Vincent Charlton, Dawn O’Reilly, Yiannis Philippou, Srinivasa R. Rao, Alastair D.G. Lamb, Ian Geoffrey Mills, Geoff Stuart Higgins, Freddie Charles Hamdy, Clare L. Verrill, Francesca Meteora Buffa, Richard J. Bryant

bioRxiv · Sep 4, 2023 · PreprintGenomics

Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of cancer

Andrew M. Erickson, Sandy Figiel, Timothy Rajakumar, Srinivasa R. Rao, Wencheng Yin, Dimitrios Doultsinos, Anette Magnussen, Reema Singh, Ninu Poulose, Richard J. Bryant, Olivier Cussenot, Freddie Charles Hamdy, Dan J. Woodcock, Ian Geoffrey Mills, Alastair D.G. Lamb

The paper evaluates the accuracy of transcript-based inferred tumor phylogenies compared to DNA-based phylogenies in prostate cancer using single-cell, spatial transcriptomic, and bulk data.

bioRxiv · Feb 26, 2023 · PreprintBioinformatics

The spatial landscape of clonal somatic mutations in benign and malignant tissue

Andrew M. Erickson, Emelie Berglund, Mengxiao He, Maja Marklund, Reza Mirzazadeh, Niklas Schultz, Ludvig Bergenstråhle, Linda Kvastad, Alma Andersson, Joseph Bergenstråhle, Ludvig Larsson, Alia Shamikh, Elisa Basmaci, Teresita Díaz de Ståhl, Timothy Rajakumar, , Joakim Lundeberg

The paper uses spatial transcriptomics to analyze copy number variations in benign and malignant tissues, revealing clonal patterns and suggesting early cancer evolution mechanisms.

bioRxiv · Jul 12, 2021 · PreprintGenomics