Frédéric Flamant

Thyroid hormones maintain parvalbumin neuron functions in the mouse neocortex

This study shows that thyroid hormones are essential for maintaining the function of mature parvalbumin neurons in the mouse neocortex, affecting behavior, sleep, and neural oscillations.

Thyroid hormones act as a timer for the postnatal maturation of parvalbumin neurons in the neocortex

This study identifies thyroid hormones as a timer for postnatal maturation of parvalbumin neurons in the mouse neocortex by analyzing gene expression and cellular development.

Extrahepatic effects of thyroid hormone and resmetirom override their beneficial hepatic effects in alcohol-associated liver disease in mice

The paper shows that thyroid hormone and resmetirom have harmful extrahepatic effects in white adipose tissue that counteract their beneficial effects on the liver in alcohol-associated liver disease in mice.

Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

This study shows that thyroid hormone signaling in brown adipocytes is essential for thermogenesis by regulating lipid and glucose metabolism and BAT proliferation.

An atlas of thyroid hormone receptors target genes in mouse tissues

The paper compiles RNA-seq and ChIP-seq data to create an atlas of thyroid hormone receptor target genes in mouse tissues, revealing variations in target gene repertoires and factors influencing hormonal response.

Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen

The paper uses synthetic STARR-seq to identify functional thyroid hormone response elements by assessing DNA-binding affinity and transactivation activity of TR1-RXR heterodimers.

A pivotal genetic program controlled by thyroid hormone during the maturation of GABAergic neurons in mice

This study identifies TR1-dependent gene regulation in GABAergic neurons during post-natal maturation, revealing a critical role for thyroid hormone in neurodevelopment.