Martin Lochner

The paper identifies the binding site of small molecule inhibitors NBA and IBA in TRPM4 using cryo-EM and patch clamp experiments.

This paper investigates threonine metabolism in Echinococcus multilocularis metacestodes, identifies threonine dehydrogenase (TDH) as a drug target, and shows that sanguinarine inhibits TDH and parasite growth.

This paper develops fluorescent probes EvoSiR4 and EvoSiR6 that potently and specifically label CaSR in vitro, in vivo, and ex vivo, outperforming evocalcet and its linker conjugate.

The paper compares the effects of BnOCPA, an A1R agonist, in rat and mouse hippocampal neurons, finding differences in its functional selectivity between pre- and postsynaptic receptors.