Clément Regnault

Alzheimer's disease risk gene Wwox protects against amyloid pathology through metabolic reprogramming

This study identifies Wwox as a protective factor against Alzheimer's disease by modulating metabolic pathways and reducing amyloid pathology in a Drosophila model.

Investigation of the threonine metabolism of Echinococcus multilocularis: the threonine dehydrogenase as a potential drug target in alveolar echinococcosis

This paper investigates threonine metabolism in Echinococcus multilocularis metacestodes, identifies threonine dehydrogenase (TDH) as a drug target, and shows that sanguinarine inhibits TDH and parasite growth.

Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate.

This study investigates the combination of artesunate and arsenic trioxide to treat AML with reduced off-target effects on normal hematopoietic stem cells.

Alignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

This study aligns metabolomics LC-MS datasets from malaria, leishmaniasis, and Zika virus to identify fever-associated metabolites, finding the kynurenine pathway as most affected.

Transcriptional shift and metabolic adaptations during Leishmania quiescence using stationary-phase and drug pressure as models

The paper quantifies transcriptome and metabolome changes in Leishmania during quiescence induced by drug pressure or stationary phase, revealing global transcriptional reduction and specific upregulation of membrane and autophagy-related genes.