April E. Hartley

The paper identifies tissue-specific protein regulation and pQTLs associated with cardiometabolic disease using multi-tissue proteomic data from STARNET patients.

This study uses Mendelian randomization to identify two proteins, CCL27 and TNFRSF14, that influence subsequent cardiovascular events after a stroke, suggesting inflammation as a contributing factor.

This study identifies genetic correlations and colocalizing signals between type 2 diabetes and osteoarthritis, highlighting shared pathways and effector genes.

This study uses GWAS and Mendelian randomization to show that lower sclerostin levels increase risk of hypertension, type 2 diabetes, myocardial infarction, and atherogenic lipid profiles.

This study identifies genetic determinants of hip joint space width and finds they have opposing causal effects on hip osteoarthritis risk through distinct mechanisms.

This paper reviews statistical methods to detect and adjust for collider bias in genetic and Mendelian randomization studies of disease progression using individual and summary-level data.

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

The paper identifies 40 novel genetic loci associated with longitudinal pediatric bone accrual and identifies candidate effector genes through variant-to-gene mapping and functional validation.

A rare SMAD9 mutation is linked to high bone mass, suggesting the BMP pathway as a potential osteoanabolic target.