BiochemistrybioRxivPreprint
O-mannosylation of fibrocystin and fibrocystin-L expands TMEM260 sequon selectivity and provides a potential link to the renal and auditory phenotypes of SHDRA
Jonas Till Kaynert, Christina Hopf, S. Brand…·Falk F. R. Buettner
This study identifies fibrocystin and fibrocystin-L as TMEM260 substrates, showing that TMEM260-mediated O-mannosylation is disrupted by disease-associated mutations, potentially linking TMEM260 dysfunction to renal phenotypes in SHDRA and ARPKD.
DOI 10.64898/2026.09.21.753134