Andreas Pich

This study identifies fibrocystin and fibrocystin-L as TMEM260 substrates, showing that TMEM260-mediated O-mannosylation is disrupted by disease-associated mutations, potentially linking TMEM260 dysfunction to renal phenotypes in SHDRA and ARPKD.

This study identifies a non-catalytic role of METTL3 in regulating exocytosis and the cancer secretome through stabilization of EXOC7.

This study shows Sorafenib causes muscle wasting by disrupting chromatin regulators, leading to transcriptional changes and impaired muscle function.

This study shows SGLT2 inhibitors reduce endothelial to mesenchymal transition and cardiac fibroblast activation through effects on mitochondrial respiration, actin cytoskeleton, and specific transporters.