Sean P. Ryder

This study investigates how the glp-1 3'UTR regulates germline proliferation and fecundity through interactions with RNA-binding proteins POS-1 and GLD-1, revealing distinct mechanisms for each.

The paper shows that the pos-1 3'UTR regulates POS-1 expression in C. elegans, affecting germline specification and reproductive robustness under stress.

This study identifies a conserved triple arginine motif in OMA-1 essential for RNA-binding and embryo viability in C. elegans.

The paper shows that the mex-3 3UTR is essential for fertility under temperature stress by buffering MEX-3 expression in oocytes and embryos.

This paper describes a microdeletion allele in C. elegans generated via CRISPR/Cas9, which removes 32 genes and causes complex developmental phenotypes.

The paper shows that multiple RNA regulatory pathways control the spatiotemporal expression of the conserved germline RNA-binding protein MEX-3, with redundant mechanisms ensuring its function despite regulatory disruptions.

The paper analyzes SARS-CoV-2 genomic sequences to identify rapidly emerging variants in structured cis-regulatory elements and their potential functional impacts.