Author

Rico Chandra Ardy

Memorial Sloan Kettering Cancer CenterORCID 0000-0003-4975-2177Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:CRISPR screen· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Thomas M. NormaniD· 4 shared Eli MetzneriD· 3 shared Anran TangiD· 2 shared Kaden M. SouthardiD· 2 shared Karthik GuruvayurappaniD· 2 shared Kushal K. DeyiD· 2 shared Allison J. Vela· 1 shared Ann Le· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersSystems Biology

Thomas M. NormanORCID

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4 papers

Recent·Most cited

Host control and regulation of human anellovirus persistence

Jacob C. Gutierrez, Thahmina A. Ali, C. Cole Honeycutt, Jun Hao Neo, Konstantin Helmsauer, Sherry S. Nyeo, Ann Le, Allison J. Vela, Laura C. Kida, Austin A. Varela, Rico C. Ardy, Eli Metzner, Jacob C. Ulirsch, Ryan S. Dhindsa, Petko P. Fiziev, , Caleb A. Lareau

This study identifies host factors and cellular contexts governing anellovirus persistence through genomic, transcriptomic, and functional analyses.

bioRxiv · Nov 9, 2026 · PreprintGenetics

Engineered regulatory states resolve context-dependent genetics in macular degeneration

Eli Metzner, Karthik Guruvayurappan, Kaden M. Southard, Rico Chandra Ardy, Kushal K. Dey, Thomas M. Norman

The paper uses CRISPR activation to engineer regulatory states in RPE-1 cells, revealing hidden genetic effects in AMD by analyzing chromatin accessibility and transcriptional interactions.

bioRxiv · Oct 12, 2026 · PreprintSystems Biology

Scaling perturbations: beyond genome-scale CRISPR screens

Anran Tang, Rico Chandra Ardy, Rafaela Mendes, Thomas M. Norman

The paper introduces two technologies to enhance CRISPR screening, enabling large-scale genetic interaction mapping in human cells using non-fitness phenotypes.

bioRxiv · Jan 17, 2026 · PreprintSystems Biology

Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states

Kaden M. Southard, Rico Chandra Ardy, Anran Tang, D. O'Sullivan, Eli Metzner, Karthik Guruvayurappan, Thomas M. Norman

The paper uses CRISPRa Perturb-seq to perturb transcription factors in fibroblasts, recapitulating in vivo transcriptional states and identifying key regulators.

Nature Genetics · Aug 6, 2025Peer-reviewedSystems Biology