Eli Metzner

Host control and regulation of human anellovirus persistence

This study identifies host factors and cellular contexts governing anellovirus persistence through genomic, transcriptomic, and functional analyses.

Engineered regulatory states resolve context-dependent genetics in macular degeneration

The paper uses CRISPR activation to engineer regulatory states in RPE-1 cells, revealing hidden genetic effects in AMD by analyzing chromatin accessibility and transcriptional interactions.

Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states

The paper uses CRISPRa Perturb-seq to perturb transcription factors in fibroblasts, recapitulating in vivo transcriptional states and identifying key regulators.

Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome

The paper introduces Multiome Perturb-seq to simultaneously measure gene expression and chromatin accessibility in CRISPR screens, revealing regulatory programs in human cells.

A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brains

The paper develops a high-throughput single-cell genomics approach to study age-related and Alzheimer's disease-associated cell population dynamics and molecular signatures in human and mouse brains.

Advanced eMAGE for highly efficient combinatorial editing of a stable genome

This paper optimizes eMAGE to achieve high-efficiency combinatorial genome editing in yeast with reduced spontaneous mutations and faster workflow.