Author
Memorial Sloan Kettering Cancer CenterORCID 0000-0003-3791-8387Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Eli Metzner, Karthik Guruvayurappan, Kaden M. Southard…·Thomas M. Norman
The paper uses CRISPR activation to engineer regulatory states in RPE-1 cells, revealing hidden genetic effects in AMD by analyzing chromatin accessibility and transcriptional interactions.
Kaden M. Southard, Rico Chandra Ardy, Anran Tang…·Thomas M. Norman
The paper uses CRISPRa Perturb-seq to perturb transcription factors in fibroblasts, recapitulating in vivo transcriptional states and identifying key regulators.
Rachel A. Glenn, C. Stephanie, Karthik Guruvayurappan…·Thomas Vierbuchen
This paper establishes a pluripotent stem cell platform using genetically diverse mouse lines to study the impact of natural genetic variation on development and gene regulation.
Jessica Zhou, Karthik Guruvayurappan, Shushan Toneyan…·Graham McVicker
The paper analyzes single-cell CRISPR perturbations to show enhancers act multiplicatively with limited evidence for epistatic interactions.
Hsiuyi V. Chen, Michael H. Lorenzini, Shanna N. Lavalle…·Graham McVicker
The paper identifies a distal enhancer for GATA3 involved in allergic diseases by combining GWAS signals with deletion mapping in T helper 2 cells.