Author
Memorial Sloan Kettering Cancer CenterORCID 0000-0002-5017-0687Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Eli Metzner, Karthik Guruvayurappan, Kaden M. Southard…·Thomas M. Norman
The paper uses CRISPR activation to engineer regulatory states in RPE-1 cells, revealing hidden genetic effects in AMD by analyzing chromatin accessibility and transcriptional interactions.
Kaden M. Southard, Rico Chandra Ardy, Anran Tang…·Thomas M. Norman
The paper uses CRISPRa Perturb-seq to perturb transcription factors in fibroblasts, recapitulating in vivo transcriptional states and identifying key regulators.
Eli Metzner, Kaden M. Southard, Thomas M. Norman
The paper introduces Multiome Perturb-seq to simultaneously measure gene expression and chromatin accessibility in CRISPR screens, revealing regulatory programs in human cells.