Cell BiologybioRxivPreprint
Constitutive cGAS-STING activation in ALT+ cells
Dan Geelen, Alexander Beacom, Mélina Vaurs…·Anabelle Decottignies
The paper reveals how ALT+ cells sustain cGAS-STING activation through spatial regulation and lysosomal degradation of STING and ECTR species, suggesting therapeutic targets for ALT+ tumors.
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