Author

Andrew P. Yu

Harvard UniversityORCID 0009-0000-1682-5232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Lance L. MunniD· 2 shared Xingjian ZhangiD· 2 shared Dingyao ZhangiD· 1 shared Michael MakiD· 1 shared Rakesh K. JainiD· 1 shared Xiangyu GongiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

Lance L. MunnORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJan 30, 2026

Volumetric mechanoplasticity couples melanoma drug tolerance to susceptibility to CD8+ T cell killing

Xingjian Zhang, Dingyao Zhang, Xiangyu Gong…·Michael Mak

The paper shows that sustained cell volume expansion in melanoma primes cells to develop drug tolerance while increasing susceptibility to CD8+ T cell killing.

DOI 10.64898/2026.01.27.701903

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintOct 21, 2025

Optimizing T-cell-mediated cancer killing: An agent-based model

Andrew P. Yu, Xingjian Zhang, Lance L. Munn

This study uses an agent-based model to simulate T-cell interactions with tumors and identifies parameter optimizations that enhance tumor clearance.

DOI 10.1101/2025.10.21.683801

deep learningstatistical model

𝕏 PostBluesky