Xingjian Zhang

The paper shows that sustained cell volume expansion in melanoma primes cells to develop drug tolerance while increasing susceptibility to CD8+ T cell killing.

This study shows that breast tumors impair antigen presentation in local lymph nodes, which can be overcome by delivering IL1β or adjuvants to distant lymph nodes, improving anti-cancer immune responses.

This study uses an agent-based model to simulate T-cell interactions with tumors and identifies parameter optimizations that enhance tumor clearance.