Excitability as a Design Principle in the Immune System
The paper identifies excitability as a unifying design principle in immune circuits, showing its presence in diverse immune subsystems and responses to pathogens and autoimmunity.
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Weizmann Institute of ScienceORCID 0009-0000-1865-7543Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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The paper identifies excitability as a unifying design principle in immune circuits, showing its presence in diverse immune subsystems and responses to pathogens and autoimmunity.
Yael Lebel, Avni S. Gupta, Victoria Chevée…·David S. Schneider
The paper identifies five immune response archetypes in mice infected with Plasmodium chabaudi and shows tradeoffs between resistance to different pathogens.
Yael Lebel, Tomer Milo, Alon Bar…·Uri S. Alon
This paper models autoimmune disease flares as excitable dynamics, showing how stochastic events trigger relapses and how regulatory cells influence their frequency.