Author

Bryant Xu

Innovative Genomics InstituteORCID 0009-0000-2464-6111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Jennifer A. DoudnaiD· 2 shared Kai CheniD· 2 shared Amy R. EggersiD· 1 shared Atip LawanprasertiD· 1 shared Benjamin W. BurgstoneiD· 1 shared Boyan YiniD· 1 shared Brittney W. ThorntoniD· 1 shared Erin E. DohertyiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Jennifer A. DoudnaORCID

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2 papers

Recent·Most cited

Molecular BiologyCellPeer-reviewedMay 22, 2024

Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9

Amy R. Eggers, Kai Chen, Katarzyna M. Soczek…·Jennifer A. Doudna

The paper shows that engineered GeoCas9 variants enhance genome editing by accelerating DNA unwinding, revealing a new role for the WED domain in this process.

78 citationstop 1%

humanCRISPR screen

𝕏 PostBluesky

BioengineeringbioRxivNov 15, 2023

Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 RNP

Kai Chen, Hesong Han, Sheng Zhao…·Jennifer A. Doudna

This study demonstrates that lipid nanoparticle-delivered thermostable Cas9 RNPs achieve high-efficiency genome editing in mouse liver and lung tissues.

DOI 10.1038/s41587-024-02437-3

mouseCRISPR screen

𝕏 PostBluesky