Author

Nyles W. Charon

West Virginia UniversityORCID 0009-0000-2734-7467Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Brian R. CraneiD· 2 shared Michael J. LynchiD· 2 shared Chunhao LiiD· 1 shared Kurni KurniyatiiD· 1 shared Maithili DeshpandeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

Brian R. CraneORCID

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2 papers

Recent·Most cited

MicrobiologyJournal of BacteriologyPeer-reviewedOct 29, 2026

Lysinoalanine crosslinking in the extracellular flagellar hook of Synergistota

Michael J. Lynch, Nyles W. Charon, Brian R. Crane

The paper identifies lysinoalanine crosslinking in the extracellular flagellar hook of Synergistota, expanding the known range of bacteria with this modification beyond spirochetes.

DOI 10.1128/jb.00407-26

proteomicsexperimental assay

𝕏 PostBluesky

BiochemistryACS Chemical BiologyPeer-reviewedFeb 25, 2025

Inhibitors of lysinoalanine crosslinking in the flagella hook as antimicrobials against spirochetes

Michael J. Lynch, Kurni Kurniyati, Maithili Deshpande…·Brian R. Crane

This study identifies two clinically approved small molecules that inhibit lysinoalanine crosslinking in spirochete flagella, reducing bacterial motility and suggesting a new therapeutic approach.

4 citations

humanproteomics

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