Rowan S. Wooldridge

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

This study shows that ApoE4 lipidation state affects human microglial metabolism and function, with lipid-bound ApoE4 causing metabolic reprogramming and lipid-free ApoE4 inducing inflammatory signaling.

This paper develops a genetic code expansion platform for in vivo study of lysine acetylation in non-model bacteria, demonstrating its use in a non-E. coli strain.