Jasmin S. Revanna

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

The paper develops a Cre-dependent CRISPR-dCas9 system for gene regulation in neurons, showing improved specificity over traditional methods.

This paper improves CRISPR/dCas9 interference for neuronal gene suppression by using a dual lentivirus system and dCas9-KRAB-MeCP2 construct, showing superior repression of the Bdnf gene in rat neurons.

The paper identifies enhancer-gene regulatory links using eRNAs and shows their functional importance in neuronal systems.

This paper develops a neuron-optimized CRISPRa system for efficient and specific gene regulation in neurons and the adult brain.