Author
Pacific Northwest National LaboratoryORCID 0009-0007-4941-2048Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Samantha A. Obermiller, Mary S. Weir Lipton, Paul Piehowski…·Isaac Kwame Attah
The paper develops a computationally efficient, library-free DIA workflow for metaproteomics, improving throughput and reducing reliance on spectral libraries.
Jasmin S. Revanna, Karl A. Wessendorf-Rodriguez, Qiang Xiao…·Fred H. Gage
This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.
Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker…·Kimberley D. Bruce
This study shows that ApoE4 lipidation state affects human microglial metabolism and function, with lipid-bound ApoE4 causing metabolic reprogramming and lipid-free ApoE4 inducing inflammatory signaling.