An RNA Language Model trained on sequence alone reveals the structural logic of Internal Ribosome Entry Sites
Adam Sychla, Pierre Bongrand, Grant Yang, Anoop Krishnan, Jacob Rulison, R. Alexander Wesselhoeft, Namita Bisaria, Silvi Rouskin
Continued pretraining of an RNA language model on picornaviral 5′ UTRs alone predicts IRES base pairs with median precision 0.80 versus 0.47 for Infernal, and reveals a Type II subclass.
bioRxiv · Sep 24, 2026 · PreprintMolecular Biology✦ In-depth digest