Adam Sychla

An RNA Language Model trained on sequence alone reveals the structural logic of Internal Ribosome Entry Sites

Continued pretraining of an RNA language model on picornaviral 5′ UTRs alone predicts IRES base pairs with median precision 0.80 versus 0.47 for Infernal, and reveals a Type II subclass.

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells

The paper identifies a genetic variant associated with reduced blood counts and cancer protection, showing it disrupts a lncRNA that regulates HOXA gene expression in hematopoietic stem cells.

Heterologous expression of microbial nitroreductases for TNT degradation in transgenic animals

The paper engineers Drosophila melanogaster to express microbial nitroreductases for TNT degradation screening, finding cofactor-dependent activity in fly lysates.

High-throughput investigation of genetic design constraints in domesticated Influenza A Virus for transient gene delivery

The paper investigates genetic design constraints in domesticated Influenza A Virus for transient gene delivery, identifying permissible mutations and RNA level motif depletion.