Silvi Rouskin

Continued pretraining of an RNA language model on picornaviral 5′ UTRs alone predicts IRES base pairs with median precision 0.80 versus 0.47 for Infernal, and reveals a Type II subclass.

The paper identifies a structural gate in pre-mRNA that regulates U1 recruitment and nutrient-stress adaptation in yeast.

The paper identifies a genetic variant associated with reduced blood counts and cancer protection, showing it disrupts a lncRNA that regulates HOXA gene expression in hematopoietic stem cells.

The paper introduces a diverse RNA structure database and a deep learning model, eFold, which improves RNA secondary structure prediction by emphasizing structural diversity over database size.

This study identifies viral lncRNAs that regulate EBV reactivation by interacting with CTCF and modulating enhancer-promoter looping.

SEISMICgraph is a web-based tool for visualizing RNA structure data from chemical probing experiments, enabling comparison across sequences and conditions.

The paper applies an updated DMS-MaPseq protocol to characterize RNA structures and identify antisense oligonucleotide binding sites.

The paper identifies KREH2 helicase as a repressor of ND7 mRNA editing in T. brucei by modulating canonical and moonlighting gRNA utilization, revealing its dual role in developmental editing control.

The paper maps the human mitochondrial mRNA structurome using a novel method, revealing novel mechanisms of gene expression and the role of LRPPRC in mRNA stability.

The paper shows that RNA folding in germ granules limits intermolecular base pairing, which is essential for normal fly development.

The paper introduces SEARCH-MaP and SEISMIC-RNA to discover and quantify long-range RNA base pairs in coronaviruses, revealing their role in ribosomal frameshifting.

The paper shows that pre-mRNA splicing order in human cells is largely predetermined and conserved across cell types and differentiation stages, ensuring splicing fidelity.