Cancer BiologybioRxivPreprint
PITPβ Drives JAK2 V617F-Mediated Myeloproliferative Neoplasms by Promoting PtdIns(3,4)P2-Dependent AKT Hyperactivation
Nikita Vantsev, Liang Zhao, Shin Morioka…·Wei Tong
This study identifies PITPβ as a critical driver of JAK2 V617F-mediated myeloproliferative neoplasms by promoting PtdIns(3,4)P2-dependent AKT hyperactivation, suggesting therapeutic targeting of this pathway.
DOI 10.64898/2026.03.26.714558