Wei Tong

This study identifies PITPβ as a critical driver of JAK2 V617F-mediated myeloproliferative neoplasms by promoting PtdIns(3,4)P2-dependent AKT hyperactivation, suggesting therapeutic targeting of this pathway.

The paper examines rRNA transcription and abundance in normal and leukemic hematopoiesis, finding cell-type-specific variations and functional roles in myeloid differentiation.

This study shows that platelet inhibition increases rupture risk in early abdominal aortic aneurysm models in mice.

This study shows that RUNX1 in granulocyte-monocyte progenitors limits neutrophil inflammatory cytokine production by restricting retrotransposon chromatin accessibility and type I interferon signaling.

This study shows that RUNX1 haploinsufficiency reduces megakaryocyte-biased hematopoietic progenitor cells and identifies drug targets to correct this defect.