Author

Junko Sasaki

Institute of Science TokyoORCID 0000-0002-2469-3791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Hiroaki KajihoiD· 2 shared Shin MoriokaiD· 2 shared Takehiko Sasaki· 2 shared Akari HagiwaraiD· 1 shared Akira Katayanagi· 1 shared Charles S. AbramsiD· 1 shared Christoph ThieleiD· 1 shared Eija JokitaloiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

Hiroaki KajihoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PLCXD2 preferentially hydrolyzes phosphatidylinositol and supports retinal lipid homeostasis and photoreceptor integrity

Kaori Kanemaru, Wako Iwata, Akira Katayanagi, Fusui Oka, Yuto Kikuchi, Nozomu Kono, Hyeon‐Cheol Lee, Hideto Osada, Hiroaki Kajiho, Junya Hasegawa, Shin Morioka, Junko Sasaki, Akari Hagiwara, Norimitsu Ban, Junken Aoki, , Yoshikazu Nakamura

This study identifies PLCXD2 as a phosphatidylinositol-preferring phospholipase that maintains retinal lipid homeostasis and photoreceptor integrity.

bioRxiv · Sep 18, 2026 · PreprintBiochemistry

PITPβ Drives JAK2 V617F-Mediated Myeloproliferative Neoplasms by Promoting PtdIns(3,4)P2-Dependent AKT Hyperactivation

Nikita Vantsev, Liang Zhao, Shin Morioka, Hiroaki Kajiho, Junko Sasaki, Takehiko Sasaki, Charles S. Abrams, Wei Tong

This study identifies PITPβ as a critical driver of JAK2 V617F-mediated myeloproliferative neoplasms by promoting PtdIns(3,4)P2-dependent AKT hyperactivation, suggesting therapeutic targeting of this pathway.

bioRxiv · Mar 30, 2026 · PreprintCancer Biology

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol

Xin Zhou, Miesje M. van der Stoel, Shreyas Kaptan, Haoran Li, Shiqian Li, Maarit Hölttä‐Vuori, Helena Vihinen, Eija Jokitalo, Christoph Thiele, Olli P. H. Pietiläinen, Shin Morioka, Junko Sasaki, Takehiko Sasaki, Ilpo Vattulainen, Elina Ikonen

This study shows that Sac1 regulates Golgi V-ATPase assembly by controlling TGN membrane composition through lipid exchange, leading to Golgi fragmentation and impaired glycosylation.

Nature Communications · Aug 21, 2025Peer-reviewedCell Biology