BiochemistrybioRxivPreprint
Peripheral mutations underlie promiscuous transport of quaternary ammonium antiseptics by Small Multidrug Resistance transporters
Olive E. Burata, Ever O’Donnell, Jeonghoon Hyun…·Randy B. Stockbridge
The paper identifies peripheral mutations that enable promiscuous transport of quaternary ammonium antiseptics by SMR transporters, revealing that substrate preference changes through mutations outside the binding pocket.
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